The principal cytochrome P450 isoenzyme included appears to be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Around 85% of the oral dose seems inside the urine within 24 hrs of administration, most as being the glucuronide conjugate, with smaller quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity information and fac